Novel orally active NPY Y5 receptor antagonists: Synthesis and structure-activity relationship of spiroindoline class compounds.
Bioorg Med Chem
; 17(14): 5015-26, 2009 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-19525116
ABSTRACT
Spiroindoline urea derivatives, designed to act as NPY Y5 receptor antagonists, were synthesized and their structure-activity relationships were investigated. Of these derivatives, compound 3a showed good Y5 binding affinity with favorable pharmacokinetic properties. Compound 3a significantly inhibited bPP Y5 agonist-induced food intake in rats, and suppressed body weight gain in DIO mice.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Neuropeptídeo Y
/
Fármacos Antiobesidade
/
Indóis
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article