Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda.
Trop Med Int Health
; 14(8): 910-7, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19552645
ABSTRACT
OBJECTIVE:
To identify risk factors for in-hospital mortality in patients treated for visceral leishmaniasis (VL) in Uganda.METHODS:
Retrospective analysis of VL patients' clinical data collected for project monitoring by Médecins Sans Frontières in Amudat, eastern Uganda.RESULTS:
Between 2000 and 2005, of 3483 clinically suspect patients, 53% were confirmed with primary VL. Sixty-two per cent were children <16 years of age with a male/female ratio of 2.2. The overall case-fatality rate during pentavalent antimonial (n = 1641) or conventional amphotericin B treatment (n = 217) was 3.7%. There was no difference in the case-fatality rate between treatment groups (P > 0.20). The main risk factors for in-hospital death identified by a multivariate analysis were age <6 years and >15 years, concomitant tuberculosis or hepatopathy, and drug-related adverse events. The case-fatality rate among patients >45 years of age was strikingly high (29.0%).CONCLUSION:
Subgroups of VL patients at higher risk of death during treatment with drugs currently available in Uganda were identified. Less toxic drugs should be evaluated and used in these patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mortalidade Hospitalar
/
Leishmaniose Visceral
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Antiprotozoários
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
/
Male
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Middle aged
/
Newborn
País/Região como assunto:
Africa
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article