Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample.
Neurosci Lett
; 462(2): 105-8, 2009 Sep 22.
Article
em En
| MEDLINE
| ID: mdl-19560517
ABSTRACT
Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P=0.01) and rs3918342 (P=0.02), and a highly significant under-transmission between haplotype CAT (P=0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Proteínas de Transporte
/
Predisposição Genética para Doença
Limite:
Adult
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Female
/
Humans
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Male
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article