Biaryl polyamides as a new class of DNA quadruplex-binding ligands.

Rahman, Khondaker M; Reszka, Anthony P; Gunaratnam, Mekala; Haider, Shozeb M; Howard, Philip W; Fox, Keith R; Neidle, Stephen; Thurston, David E

Rahman, Khondaker M; Reszka, Anthony P; Gunaratnam, Mekala; Haider, Shozeb M; Howard, Philip W; Fox, Keith R; Neidle, Stephen; Thurston, David E.

Afiliação

Rahman KM; Gene Targeted Drug Design Research Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London, UK WC1N 1AX.

Chem Commun (Camb) ; (27): 4097-9, 2009 Jul 21.

Article em En | MEDLINE | ID: mdl-19568645

ABSTRACT

ABSTRACT

We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.

Assuntos

Antineoplásicos/farmacologia; Quadruplex G/efeitos dos fármacos; Nylons/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Dicroísmo Circular; Fibroblastos/efeitos dos fármacos; Fibroblastos/metabolismo; Humanos; Concentração Inibidora 50; Ligantes; Nylons/síntese química; Nylons/química

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quadruplex G / Antineoplásicos / Nylons Limite: Humans Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google