New sources of chemical diversity inspired by biosynthesis: rational design of a potent epothilone analogue.
Org Lett
; 11(15): 3186-9, 2009 Aug 06.
Article
em En
| MEDLINE
| ID: mdl-19572566
ABSTRACT
A concise total synthesis of (S)-14-methoxyepothilone D has been accomplished. (S)-14-Methoxyepothilone D represents a conceptually novel example of polyketide analogue design based on an alternative biogenetic pattern of extender units. The significant biological activity observed for this compound provides a foundation to support studies designed to prepare derivatives of this type through fermentation of genetically engineered organisms expressing the epothilone PKS gene cluster.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Macrolídeos
/
Epotilonas
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article