Exploring symmetry-based logic for a synthesis of palau'amine.
J Org Chem
; 74(16): 5909-19, 2009 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-19603820
ABSTRACT
A synthetic approach to palau'amine is described that exploits veiled symmetry in the structure. Bis-alkylidenes i have been prepared and found susceptible to halogenative desymmetrization using t-BuOCl. This oxidation forms the imbedded spirocyclopentane motif observed in the natural product. A host of atypical reactions and processes developed during these studies are discussed, as are plans for completing total syntheses of this compound class.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Espiro
/
Guanidinas
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article