Novel translation products from simian immunodeficiency virus SIVmac239 Env-encoding mRNA contain both Rev and cryptic T-cell epitopes.
J Virol
; 83(19): 10280-5, 2009 Oct.
Article
em En
| MEDLINE
| ID: mdl-19605480
ABSTRACT
Understanding the correlates of immune protection against human immunodeficiency virus and simian immunodeficiency virus (SIV) will require defining the entire cellular immune response against the viruses. Here, we define two novel translation products from the SIV env mRNA that are targeted by the T-cell response in SIV-infected rhesus macaques. The shorter product is a subset of the larger product, which contains both the first exon of the Rev protein and a translated portion of the rev intron. Our data suggest that the translation of viral alternate reading frames may be an important source of T-cell epitopes, including epitopes normally derived from functional proteins.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
/
RNA Mensageiro
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RNA Viral
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Regulação Viral da Expressão Gênica
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Produtos do Gene rev
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Vírus da Imunodeficiência Símia
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Epitopos de Linfócito T
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article