Linkage disequilibrium extends across putative selected sites in FOXP2.
Mol Biol Evol
; 26(10): 2181-4, 2009 Oct.
Article
em En
| MEDLINE
| ID: mdl-19608635
ABSTRACT
Polymorphism data in humans suggest that the gene encoding the transcription factor FOXP2, which influences speech and language development, has been subject to a selective sweep within the last 260,000 years. It has been proposed that one or both of two substitutions that occurred on the human evolutionary lineage and changed amino acids were the targets for selection. In apparent contradiction to this is the observation that these substitutions are present in Neandertals who diverged from humans maybe 300,000-400,000 years ago. We have collected polymorphism data upstream and downstream of the substitutions. Contrary to what is expected, following a selective sweep, we find that the haplotypes extend across the two sites. We discuss possible explanations for these observations. One of them is that the selective sweep reflected in FOXP2 polymorphism data was not associated with the two amino acid substitutions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desequilíbrio de Ligação
/
Fatores de Transcrição Forkhead
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article