The effectiveness of prenatal serum biomarker screening for neural tube defects in second trimester pregnant women: a meta-analysis.
Prenat Diagn
; 29(10): 960-5, 2009 Oct.
Article
em En
| MEDLINE
| ID: mdl-19609892
ABSTRACT
BACKGROUND:
Neural tube defects (NTDs) are common and serious birth defects all over the world. Prenatal screening for NTDs using maternal serum alpha-fetoprotein (MSAFP) during the second trimester of pregnancy has been widely used, but its effectiveness remains unclear.METHODS:
We evaluated the studies published in the English and Chinese on MSAFP screening for NTDs. The homogeneity of the studies was evaluated by the forest graph. Meta-analysis was applied to calculate the combined effect values and their 95% confidence intervals.RESULTS:
As many as 22 articles were selected according to the criteria and were included in the meta-analysis, for a total of 684,140 pregnant women screened during the second trimester. All the studies selected were homogenous according to the forest graph (chi(2) = 25.17, P > 0.10). The combined relative risk estimate was 0.25 and its 95% confidence interval was 0.21 to 0.29. The combined protective rate was 75%. The sensitivity and specificity of MSAFP screening were 75.1 and 97.7%, respectively.CONCLUSION:
Use of MSAFP during the second trimester in pregnant women is an effective measure for the screening of NTDs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Segundo Trimestre da Gravidez
/
Diagnóstico Pré-Natal
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Biomarcadores
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Defeitos do Tubo Neural
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
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Prognostic_studies
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Screening_studies
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Systematic_reviews
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article