Multisite solid catalyst for cascade reactions: the direct synthesis of benzodiazepines from nitro compounds.
Chemistry
; 15(35): 8834-41, 2009 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-19621393
ABSTRACT
Substituted 1,5-benzodiazepines are selectively synthesized in one pot from substituted nitroaromatics and ketones. The reaction is performed in the presence of hydrogen and in the absence of solvent by using a bifunctional solid catalyst with a chemoselective hydrogenation functional group capable of reducing the nitro group to a diamino group and an acid functional group, which catalyzes the cyclocondensation of the amino group with the ketone.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzodiazepinas
/
Nitrocompostos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article