The anticonvulsant zonisamide reduces ethanol self-administration by risky drinkers.
Am J Drug Alcohol Abuse
; 35(5): 316-9, 2009.
Article
em En
| MEDLINE
| ID: mdl-19637104
ABSTRACT
OBJECTIVE:
The purpose of this study is to examine the effects of zonisamide on ethanol self-administration and subjective effects in risky drinkers using a human laboratory paradigm.METHOD:
We conducted a double-blind, placebo-controlled study of the effects of zonisamide 100 mg on ethanol self-administration and urge to drink in risky drinkers (N = 10) ( [1] ).RESULT:
During the second hour of a 2-hour self-administration session ethanol consumption was 50% lower in the zonisamide group as compared to the placebo group. Urge to drink was also significantly lower under the zonisamide condition.CONCLUSION:
These results indicate that a single dose of zonisamide reduces urge to drink and the quantity of ethanol self-administered by risky drinkers during their second hour of access to alcohol. SCIENTIFICSIGNIFICANCE:
Zonisamide may help individuals drinking at risky levels reduce their intake of alcohol.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Consumo de Bebidas Alcoólicas
/
Etanol
/
Isoxazóis
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article