N-substituted bis-C-alkyloxadiazolones as dual effectors: efficient intermediates to amidoximes or amidines and prodrug candidates of potent antimalarials.
Bioorg Med Chem Lett
; 19(17): 5233-6, 2009 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-19643611
ABSTRACT
A convenient route to N-substituted bis-C-alkylamidines possessing antiplasmodial activity and their oxadiazolone and amidoxime prodrug candidates, is described. These three families of compounds were available after a key N-alkylation step of the parent oxadiazolone 1a. Testing of the three compound classes in vitro and in vivo is also presented.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxidiazóis
/
Oximas
/
Pró-Fármacos
/
Amidinas
/
Antimaláricos
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article