PKC differentially translocates during spaced and massed training in Aplysia.
J Neurosci
; 29(33): 10281-6, 2009 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-19692602
ABSTRACT
Learning is highly regulated by the pattern of training. In Aplysia, an important organism for the development of cellular and molecular models of learning, spaced versus massed application of the same stimulus leads to different forms of memory. A critical molecular step underlying memory is the serotonin (5HT)-mediated activation of the novel PKC Apl II. Here, we demonstrate that activation of PKC Apl II is highly sensitive to the pattern of 5HT application. Spaced applications downregulate PKC translocation through PKA signaling, whereas massed applications lead to persistent translocation of PKC. Differential regulation of PKC translocation is mediated by competing feedback mechanisms that act through protein synthesis. These studies elucidate a fundamental molecular difference between spaced and massed training protocols.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aplysia
/
Proteína Quinase C
/
Aprendizagem
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article