Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph node.
Immunity
; 31(2): 342-55, 2009 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-19699173
ABSTRACT
Memory T cells circulate through lymph nodes where they are poised to respond rapidly upon re-exposure to a pathogen; however, the dynamics of memory T cell, antigen-presenting cell, and pathogen interactions during recall responses are largely unknown. We used a mouse model of infection with the intracellular protozoan parasite, Toxoplasma gondii, in conjunction with two-photon microscopy, to address this question. After challenge, memory T cells migrated more rapidly than naive T cells, relocalized toward the subcapsular sinus (SCS) near invaded macrophages, and engaged in prolonged interactions with infected cells. Parasite invasion of T cells occurred by direct transfer of the parasite from the target cell into the T cell and corresponded to an antigen-specific increase in the rate of T cell invasion. Our results provide insight into cellular interactions during recall responses and suggest a mechanism of pathogen subversion of the immune response.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Subpopulações de Linfócitos T
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Interações Hospedeiro-Parasita
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Memória Imunológica
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Linfonodos
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Células Apresentadoras de Antígenos
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article