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Effect of selective vaccination on a decrease in the rate of hepatitis B virus-positive Japanese first-time blood donors.
Yoshikawa, A; Suzuki, K; Abe, A; Tanaka, T; Yamaguchi, K; Tanaka, T; Ishikawa, Y; Minegishi, K; Gotanda, Y; Yugi, H; Uchida, S; Satake, M; Mizoguchi, H; Tadokoro, K.
Afiliação
  • Yoshikawa A; Japanese Red Cross Saitama Blood Center, Hidaka-shi, Saitama-ken 350-1213, Japan. yoshikawa@saitama.bc.jrc.or.jp
Transfus Med ; 19(4): 172-9, 2009 Aug.
Article em En | MEDLINE | ID: mdl-19706134
ABSTRACT
The government of Japan started a selective vaccination programme to prevent mother-to-infant infection by hepatitis B virus (HBV) since January 1986. The effect of the programme on first-time blood donors has not been examined in detail. Data of first-time blood donors aged 16-25 years from 1996 to 2007 were extracted from the Japanese Red Cross (JRC) donors' database. Principal component analysis (PCA) was used to visualize the birth-year-dependent group of rate of HBV-positive donors. According to the birth of year, donors were divided into four groups by PCA. After the start of the programme, donors born in 1986-1989 comprised a single group. Before the start of the programme, three groups (1980, 1981-1984 and 1985) were identified. Although a significant time-dependent decrease in the rate of HBV-positive donors was observed before the start of the programme, a significant difference in the rate of HBV-positive donors was observed around the start of the programme by regression analysis for 16-19-year-old first-time blood donors. The selective vaccination programme has been effective to prevent the vertical transmission of HBV from the analysis of first-time blood donors. On the other hand, vaccination of blood donors should be considered to reduce the risk of post-transfusion HBV infection, because the horizontal transmission increases in HBV-positive blood donors.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Vacinação / Hepatite B Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male País/Região como assunto: Asia Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Vacinação / Hepatite B Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male País/Região como assunto: Asia Idioma: En Ano de publicação: 2009 Tipo de documento: Article