Degeneration of hippocampal CA1 neurons following transient ischemia due to raised intracranial pressure: evidence for a temperature-dependent excitotoxic process.
Brain Res
; 512(1): 169-74, 1990 Mar 26.
Article
em En
| MEDLINE
| ID: mdl-1970944
ABSTRACT
Degeneration of hippocampal CA1 neurons occurs following transient complete ischemia produced by raised intracranial pressure. Both systemic injection of MK-801 and profound cerebral hypothermia produced by cisternal infusion of room temperature (22-25 degrees C) fluids protect vulnerable CA1 neurons from degeneration. Hypothermia appears to decrease hippocampal extracellular levels of glutamate during and after ischemia but provides only relative protection from ischemia as CA1 degeneration does occur with prolonged (30 min) periods of ischemia. Elevated intracranial pressure appears to produce ischemic degeneration in the hippocampus via an NMDA receptor mediated excitotoxic process which is highly temperature dependent.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação da Temperatura Corporal
/
Pressão Intracraniana
/
Ataque Isquêmico Transitório
/
Receptores de Neurotransmissores
/
Glutamatos
/
Hipocampo
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article