Endothelin action on goat cerebral arteries.
J Pharm Pharmacol
; 42(5): 370-2, 1990 May.
Article
em En
| MEDLINE
| ID: mdl-1976792
ABSTRACT
Cumulative application of endothelin-1 (human) markedly constricted goat isolated cerebral arteries in a concentration-dependent manner. Contractile responses were not affected by removal of endothelial cells. Removal of extracellular calcium or addition of the calcium channel blocker nicardipine (10(-7) M) failed to abolish responses to endothelin. The results suggest that the endothelium-independent constriction of cerebral arteries produced by endothelin cannot be explained solely by voltage-dependent calcium channels. The contractile responses are likely to be mediated by stimulation of specific receptors for this peptide.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endotelinas
/
Músculo Liso Vascular
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article