Modelling the impact of one-dose vs. two-dose vaccination regimens on the epidemiology of varicella zoster virus in Australia.
Epidemiol Infect
; 138(4): 457-68, 2010 Apr.
Article
em En
| MEDLINE
| ID: mdl-19781116
ABSTRACT
We examined the impact of one-dose vs. two-dose vaccination strategies on the epidemiology of varicella zoster virus (VZV) in Australia, using a mathematical model. Strategies were assessed in terms of varicella (natural and breakthrough) and zoster incidence, morbidity, average age of infection and vaccine effectiveness (VE). Our modelling results suggest that compared to a one-dose vaccination strategy (Australia's current vaccination schedule), a two-dose strategy is expected to not only produce less natural varicella cases (5% vs. 13% of pre-vaccination state, respectively) but also considerably fewer breakthrough varicella cases (only 11.4% of one-dose strategy). Therefore a two-dose infant vaccination programme would be a better long-term strategy for Australia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Varicela
/
Vacinação
/
Herpesvirus Humano 3
/
Vacina contra Varicela
/
Herpes Zoster
Tipo de estudo:
Screening_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Oceania
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article