[Protective effects of affiliating portasystemic shunt on graft injury in small-for-size liver transplantation in miniature pigs].
Zhonghua Wai Ke Za Zhi
; 47(14): 1083-7, 2009 Jul 15.
Article
em Zh
| MEDLINE
| ID: mdl-19781275
ABSTRACT
OBJECTIVES:
To evaluate the protective effects of affiliating portasystemic shunt on small-for-size graft in liver transplantation.METHODS:
Fifteen Chinese Bama miniature pigs were divided into three groups group A (small-for-size liver transplantation), group B (distal splenorenal shunt + small-for-size liver transplantation), and group C (mesocaval H-shape shunt + small-for-size liver transplantation). Animals were followed up for 7 days with survival, dynamical liver function biochemical parameters, liver biopsies, portal venous pressure (PVP) and portal blood flow (PBF).RESULTS:
Animal survivals were as follows group A, 1/5, group B, 3/5 and group C, 5/5.Group A resulted in abnormal liver function parameters that were significantly ameliorated in group B and C. The histological examination of graft in group A displayed severe pathologic changes including hepatocyte vacuolar change or necrosis, sinusoidal congestion, parenchymal hemorrhage. Affiliating portasystemic shunt significantly alleviated graft injuries in group B and C. PVP rose and peaked up to 28.6 mm Hg (1 mm Hg = 0.133 kPa), PBF fluctuated after reperfusion in group A, but group B and C with affiliating portasystemic shunt showed significantly lower PVP and maintained rather stable PBF after reperfusion. There were also statistical differences in PVP or PBF between group B and C.CONCLUSIONS:
Affiliating portasystemic shunt effectively might protect small-for-size graft from injuries after reperfusion.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Derivação Portossistêmica Cirúrgica
/
Transplante de Fígado
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2009
Tipo de documento:
Article