A dynamic target-based pharmacophoric model mapping the CD4 binding site on HIV-1 gp120 to identify new inhibitors of gp120-CD4 protein-protein interactions.
Bioorg Med Chem Lett
; 19(21): 6087-91, 2009 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-19783140
ABSTRACT
A dynamic target-based pharmacophoric model mapping the CD4 binding site on HIV-1 gp120 was built and used to identify new hits able to inhibit gp120-CD4 protein-protein interactions. Two compounds showed micromolar inhibition of HIV-1 replication in cells attributable to an interference with the entry step of infection, by direct interaction with gp120. Inactivity of compounds toward a M475I strain suggested specific contacts with the Phe43 cavity of gp120.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilpropionatos
/
Ftalimidas
/
Antígenos CD4
/
Proteína gp120 do Envelope de HIV
/
HIV-1
/
Fármacos Anti-HIV
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article