Chemometric approach for improving VCSEL-based glucose predictions.
IEEE Trans Biomed Eng
; 57(3): 578-85, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-19783501
Optical methods are one of the painless and promising techniques that can be used for blood glucose predictions for diabetes patients. The use of thermally tunable vertical cavity surface-emitting lasers (VCSELs) as the light source to obtain blood absorption spectra, along with the multivariate technique partial least squares for analysis and glucose estimation, has been demonstrated. With further improvements by using data preprocessing and two VCSELs, we have achieved a clinically acceptable level in the physiological range in buffered solutions. The results of previous experiments conducted using white light showed that increasing the number of wavelength intervals used in the analysis improves the accuracy of prediction. The average prediction error, using absorption spectra from one VCSEL in aqueous solution, is about 1.2 mM. This error is reduced to 0.8 mM using absorption spectra from two VCSELs. This result confirms that increasing the number of VCSELs improves the accuracy of prediction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Lasers
/
Modelos Biológicos
/
Monitorização Fisiológica
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article