[Study of copper metabolism and liver damage in TX Mice-an animal model for liver disease].
Zhonghua Gan Zang Bing Za Zhi
; 17(9): 688-90, 2009 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-19785958
ABSTRACT
OBJECTIVE:
To provide right time points in selection of right aged animals and the normal physiological data of TX mice.METHODS:
7-12 months old TX and DL mice were studied, each group contained 3 female and 3 male mice of TX or DL mice. The concentration of copper in the serum, dry tissues (liver, brain and kidney), together with copper biochemistry indexes were measured. The liver histopathology was observed under light microscopy and electron microscope.RESULTS:
Transaminase increased significantly only in 10 and 11-month- old (AST(TX10) = 218.3 U/L, AST(TX11) = 197.5 U/L, AST(DL10) = 171.5 U/L, AST(DL11) = 165.0 U/L, P(10) less than 0.001, P(11) = 0.022), but the copper concentration of liver, brain and kidney was significantly increased during 7-12 month old (the average concentration of copper, Liver(TX) = (750.0 +/- 85.5) mg/kg, Brain(TX) = (39.7 +/- 2.2)mg/kg, Kidney(TX) = (29.8 +/- 5.0) mg/kg, Liver(DL) = (11.6 +/- 1.5) mg/kg, Brain(DL) = (16.8 +/- 0.9) mg/kg, Kidney(DL) = (14.2 +/- 1.0) mg/kg, t = 21.16, 23.60, 7.47, for all these organs P less than 0.05).CONCLUSION:
TX mice is a suitable model of liver disease with natural recovery, so selecting animal model of suitable time point is very important.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cobre
/
Fígado
/
Hepatopatias
/
Camundongos Endogâmicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2009
Tipo de documento:
Article