Human Wharton's jelly cells can be induced to differentiate into growth factor-secreting oligodendrocyte progenitor-like cells.
Differentiation
; 79(1): 15-20, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19800163
ABSTRACT
Human Wharton's jelly-derived mesenchymal stromal cells (hWJ-MSCs) are capable of differentiating into neural and astroglia-like cell types. However, a reliable means of inducing the selective differentiation of hWJ-MSCs into oligodendrocyte progenitor cells (OPCs) in vitro has not yet been established. In this study, the OPC-like differentiation of hWJ-MSCs was characterized using and immunoblotting. The hWJ-MSC-derived OPC-like cells were able to secrete nerve growth factors and promote neurite outgrowth in vitro. These results show that hWJ-MSCs can be induced to differentiate into cells with the morphologic, phenotypic and functional characteristics of OPC-like cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
/
Cordão Umbilical
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Diferenciação Celular
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Oligodendroglia
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Fator de Crescimento Neural
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Células-Tronco Mesenquimais
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Neurônios
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article