In vivo initiated rat liver carcinogenesis studied in vitro; formation of alcoholic hyaline-type bodies.
Cancer Lett
; 3(3-4): 145-50, 1977 Sep.
Article
em En
| MEDLINE
| ID: mdl-198112
ABSTRACT
Epithelial liver cells isolated from rats after oral diethylnitrosamine administration were established in culture. When propagated in vitro for 2--3 months, over half the cells contained acentric nuclei and large juxtanuclear inclusions resembling the hyaline deposits (Mallory bodies) in cirrhotic livers of alcoholics. The morphological changes and disarrayed filaments in these bodies were retained on serial passages for many months. Cells inoculated into nude mice or newborn rats produced carcinomas from which cells with these abnormalities were reestablished in continuous culture.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Corpos de Inclusão
/
Neoplasias Hepáticas
Limite:
Animals
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article