Recombinant bivalent live vaccines against neonatal colibacillosis in piglets.
Sci China B
; 33(11): 1341-9, 1990 Nov.
Article
em En
| MEDLINE
| ID: mdl-1982753
ABSTRACT
The genes of colonization factor K88 and avirulent heat-labile enterotoxin LT A-B+ of enterotoxigenic E. coli (ETEC) have been ligated, and a vaccine strain containing recombinant plasmid that efficiently expresses two antigens has been obtained. Using the activity of beta-galactosidase as a selection marker instead of drug resistance, another bivalent vaccine strain with the same expression level has also been constructed. The vaccine strains have no toxicity and do not cause any adverse reactions. In challenge study and field trials, a high degree of protection from colibacillosis was afforded to piglets when their dams were immunized orally or parenterally. Practice of bivalent live vaccines including colonization factor and enterotoxin antigens and without antibiotic resistance gene shows effective.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Suínos
/
Vacinas Sintéticas
/
Infecções por Escherichia coli
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article