The design of potent and selective inhibitors of DPP-4: optimization of ADME properties by amide replacements.
Bioorg Med Chem Lett
; 19(22): 6340-5, 2009 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-19833514
ABSTRACT
For a series of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV ADME properties were improved by the incorporation of amide replacements. These efforts led to a novel series of potent and selective inhibitors of DPP-4 that exhibit an attractive pharmacokinetic profile and show excellent efficacy in an animal model of diabetes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Relação Estrutura-Atividade
/
Inibidores da Dipeptidil Peptidase IV
/
Amidas
/
Aminobutiratos
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article