[In vitro trials with single and co-cultures of osteoblasts and endothelial cells : evaluation of new biomaterials for bone reconstruction and regeneration]. / Bewertung von neuartigen Biomaterialien zum Zweck der Knochenrekonstruktion und -regeneration : In-vitro-Versuche mit Mono- und Kokulturen von Osteoblasten und Endothelzellen.
Orthopade
; 38(11): 1020-8, 2009 Nov.
Article
em De
| MEDLINE
| ID: mdl-19838668
ABSTRACT
Many different types of bone substitute biomaterials are being developed for different applications in the body. The current dogma is that if osteoblasts and endothelial cells grow and exhibit normal cell functions on these materials in vitro as single cultures or in co-cultures, then the biomaterials are suitable for implantation for bone reconstruction and regeneration. Generally, only in vivo animal studies will prove whether this is the case. However, in vitro studies offer a good pre-screening and selection basis to evaluate the biocompatibility of novel biomaterials prior to animal studies. Multicell type co-culture systems hold a great promise for the future.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
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Regeneração Óssea
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Substitutos Ósseos
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Engenharia Tecidual
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Células Endoteliais
Limite:
Animals
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Humans
Idioma:
De
Ano de publicação:
2009
Tipo de documento:
Article