PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways.
FEBS Lett
; 583(22): 3618-24, 2009 Nov 19.
Article
em En
| MEDLINE
| ID: mdl-19850043
ABSTRACT
Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits platelet response to collagen and may also inhibit two other major platelet agonists ADP and thrombin although this has been less well explored. We hypothesized that the combined effect of inhibiting these three platelet activating pathways may act to significantly inhibit thrombus formation. We demonstrate a negative relationship between PECAM-1 surface expression and platelet response to cross-linked collagen related peptide (CRP-XL) and ADP, and an inhibitory effect of PECAM-1 clustering on platelet response to CRP-XL, ADP and thrombin. This combined inhibition of multiple signaling pathways results in a marked reduction in thrombus formation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Transdução de Sinais
/
Molécula-1 de Adesão Celular Endotelial a Plaquetas
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article