2-Amino-5-aryl-pyridines as selective CB2 agonists: synthesis and investigation of structure-activity relationships.
Bioorg Med Chem Lett
; 19(23): 6578-81, 2009 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-19864133
ABSTRACT
2-Amino-5-aryl-pyridines, exemplified by compound 1, had been identified as a synthetically tractable series of CB(2) agonists from a high-throughput screen of the GlaxoSmithKline compound collection. Described herein are the results of an investigation of the structure-activity relationships (SAR) which led to the identification a number of potent and selective agonists.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Receptor CB2 de Canabinoide
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article