Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists.
Org Biomol Chem
; 7(22): 4695-707, 2009 Nov 21.
Article
em En
| MEDLINE
| ID: mdl-19865707
ABSTRACT
The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fotólise
/
Canais de Cátion TRPV
/
Luz
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article