Protocatechuic acid inhibits rat pheochromocytoma cell damage induced by a dopaminergic neurotoxin.
Biol Pharm Bull
; 32(11): 1866-9, 2009 Nov.
Article
em En
| MEDLINE
| ID: mdl-19881299
ABSTRACT
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (SN) with the presence of alpha-synuclein inclusions termed Lewy bodies. The aggregation of alpha-synuclein into oligomeric species affects neuronal viability, having a causal role in the development of PD. The neuroprotective effects of protocatechuic acid (PAc) have been reported. However, the effects of PAc on tyrosine hydroxylase (TH) and alpha-synuclein in rat pheochromocytoma (PC12) cells treated with 1-methyl-4-phenylpyridinium ion (MPP(+)) remains unclear. In this study, we demonstrated that PAc inhibited the cytotoxicity, apoptotic morphology, reduction of TH expression and abnormal oligomeration of alpha-synuclein in PC12 cells treated with MPP(+). Taken together, our results indicate that the neuroprotective effects of PAc on PC12 cells treated with MPP(+) is related to the inhibition of the oligomerization of alpha-synuclein.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Feocromocitoma
/
Dopamina
/
Hidroxibenzoatos
/
Neurotoxinas
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article