The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain.
Gen Physiol Biophys
; 28 Spec No: 235-42, 2009.
Article
em En
| MEDLINE
| ID: mdl-19893106
ABSTRACT
The goal of the present study was to examine the effectiveness of a non-specific nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME) to modulate the toxicity of aluminium chloride (AlCl3). Rats were killed at 3 h and at 30 days after treatments and the striatum was removed. Nitrite, superoxide, superoxide dismutase activity, malondialdehyde and reduced glutathione were determined. AlCl3 exposure promoted oxidative stress in the striatum. The biochemical changes observed in neuronal tissues show that aluminium acts as pro-oxidant, while the NOS inhibitor exerts antioxidant action in AlCl3-treated rats. We conclude that L-NAME can efficiently protect neuronal tissue from AlCl3-induced toxicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Cloretos
/
Compostos de Alumínio
/
Óxido Nítrico Sintase
/
Inibidores Enzimáticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article