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Hepatocyte transplantation into the lung for treatment of acute hepatic failure in the rat.
Then, P; Sandbichler, P; Erhart, R; Dietze, O; Klima, G; Vogel, W; Margreiter, R.
Afiliação
  • Then P; Department of Transplant Surgery, University Hospital, Innsbruck, Austria.
Transplant Proc ; 23(1 Pt 1): 892-3, 1991 Feb.
Article em En | MEDLINE | ID: mdl-1990717
The lung was investigated as a matrix for transplanted hepatocytes in the rat model. Surgically induced fulminant hepatic failure was successfully treated by injection of 5 to 7 x 10(7) isolated hepatocytes into the pulmonary parenchyma in 86% of the animals. No animal, however, survived injection of hepatocytes into the jugular vein. It was found that liver failure is a prerequisite for the intrapulmonary survival of hepatocytes. After regeneration of the native liver, the majority of hepatocytes are cleared away within 6 months.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Hepatopatias Limite: Animals Idioma: En Ano de publicação: 1991 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Hepatopatias Limite: Animals Idioma: En Ano de publicação: 1991 Tipo de documento: Article