Examination of the MSX1 gene in patients with Parkinson's disease.
Acta Neurol Scand
; 120(6): 442-4, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-19922584
ABSTRACT
BACKGROUND:
Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification. AIMS OF THE STUDY To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD.METHODS:
We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing.RESULTS:
No mutation in the MSX1 gene was identified in our cohort.CONCLUSIONS:
Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Polimorfismo Genético
/
Predisposição Genética para Doença
/
Fator de Transcrição MSX1
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article