Advances in monitoring and toxicity assessment of brevetoxins in molluscan shellfish.
Toxicon
; 56(2): 137-49, 2010 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-19925816
ABSTRACT
Herein, we describe advancements in monitoring of brevetoxins in molluscan shellfish, with respect to exposure management and control of neurotoxic shellfish poisoning (NSP). Current knowledge of the fate of brevetoxins in molluscan shellfish, and the toxic potency of brevetoxin metabolites, is presented. We review rapid assays for measuring composite brevetoxins, and methodology for measuring constituent brevetoxins, in contaminated shellfish. The applicability of in vitro methods for estimating brevetoxin burden and composite toxicity in shellfish is assessed. Specific and measurable biomarkers of brevetoxin exposure and toxicity in shellfish, and of human intoxication, are described. Their utility in regulatory monitoring of toxic shellfish and in clinical diagnosis of NSP is evaluated.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dinoflagellida
/
Monitoramento Ambiental
/
Bivalves
/
Oxocinas
/
Intoxicação por Frutos do Mar
/
Toxinas Marinhas
/
Neurotoxinas
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article