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Genome sequence analysis of the first human West Nile virus isolated in Italy in 2009.
Barzon, L; Franchin, E; Squarzon, L; Lavezzo, E; Toppo, S; Martello, T; Bressan, S; Pagni, S; Cattai, M; Piazza, A; Pacenti, M; Cusinato, R; Palù, G.
Afiliação
  • Barzon L; Department of Histology, Microbiology, and Medical Biotechnologies, University of Padua, Padua, Italy.
Euro Surveill ; 14(44)2009 Nov 05.
Article em En | MEDLINE | ID: mdl-19941775
In 2009, six new human cases of West Nile neuroinvasive disease (WNND) were identified in Veneto region, following the six cases already reported in 2008. A human West Nile virus (WNV) isolate was obtained for the first time from an asymptomatic blood donor. Whole genome sequence of the human WNV isolate showed close phylogenetic relatedness to the Italy-1998-WNV strain and to other WNV strains recently isolated in Europe, with the new acquisition of the NS3-Thr249Pro mutation, a trait associated with avian virulence, increased virus transmission, and the occurrence of outbreaks in humans.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus do Nilo Ocidental / Sequência de Bases / Genoma Limite: Humans País/Região como assunto: Europa Idioma: En Ano de publicação: 2009 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus do Nilo Ocidental / Sequência de Bases / Genoma Limite: Humans País/Região como assunto: Europa Idioma: En Ano de publicação: 2009 Tipo de documento: Article