Cyano metabolite as a biomarker of nitrofurazone in channel catfish.
J Agric Food Chem
; 58(1): 313-6, 2010 Jan 13.
Article
em En
| MEDLINE
| ID: mdl-19950980
ABSTRACT
The use of nitrofuran drugs in food-producing animals continues to attract international concern as a food safety issue. Methods for monitoring nitrofuran residues have been directed to the intact side chain of tissue-bound metabolites. Semicarbazide, the side chain of nitrofurazone (NFZ), can enter food products from non-NFZ sources, suggesting the need for an alternative biomarker for confirmatory purposes. We characterized a cyano derivative as a major metabolite of NFZ in channel catfish (Ictalurus punctatus). The depletion of cyano metabolite was examined in the muscle of channel catfish after oral dosing (10 mg of NFZ/kg of body weight). Parent NFZ was rapidly eliminated in muscle, with a half-life of 6.3 h. The cyano metabolite was detected for up to 2 weeks, with an elimination half-life of 81 h. The cyano metabolite represents an alternative biomarker for confirming the use of NFZ in channel catfish.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ictaluridae
/
Resíduos de Drogas
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Contaminação de Alimentos
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Alimentos Marinhos
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Antibacterianos
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Nitrofurazona
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article