Multivalent supramolecular dendrimer-based drugs.
Biomacromolecules
; 11(1): 182-6, 2010 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-19957993
ABSTRACT
Supramolecular complexes consisting of a hydrophobic dendrimer host [DAB-dendr-(NHCONH-Ad)(64)] as well as solubilizing and bioactive guest molecules have been synthesized using a noncovalent approach. The guest-host supramolecular assembly is first preassembled in chloroform and transferred via the neat phase to aqueous solution. The bioactive guest molecules can bind to a natural (serotonin 5-HT(3)) receptor with nanomolar affinity as well as to the synthetic dendrimer receptor in aqueous solution, going toward a dynamic multivalent supramolecular construct capable of adapting itself to a multimeric receptor motif.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Água
/
Receptores 5-HT3 de Serotonina
/
Dendrímeros
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article