[Helicobacter pylori eradication therapy for peptic ulcer disease].

ABSTRACT

Meta-analyses showed that Helicobacter pylori eradication therapy was effective for healing and prevention of recurrence of peptic ulcers in H. pylori-positive patients and that treatment of H. pylori infection was more effective than antisecretory non-eradicating therapy (with or without long-term maintenance antisecretory therapy) in preventing recurrent bleeding from peptic ulcer. H. pylori eradication therapy is effective for prevention of development of NSAID-ulcers in NSAID-naïve patients. For prevention of recurrence of NSAID-ulcers, therapy with proton pump inhibitor is effective.