Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).
Bioorg Med Chem Lett
; 20(2): 499-502, 2010 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-20004097
ABSTRACT
A series of stearoyl-CoA desaturase 1 (SCD1) inhibitors were developed. Investigations of enzyme potency and metabolism led to the identification of the thiadiazole-pyridazine derivative MF-438 as a potent SCD1 inhibitor. MF-438 exhibits good pharmacokinetics and metabolic stability, thereby serving as a valuable tool for further understanding the role of SCD inhibition in biological and pharmacological models of diseases related to metabolic disorders.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridazinas
/
Estearoil-CoA Dessaturase
/
Tiadiazóis
/
Inibidores Enzimáticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article