Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia.
Leuk Lymphoma
; 50 Suppl 2: 9-15, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-20017606
ABSTRACT
The presence of the Philadelphia chromosome is a poor prognosis factor in acute lymphoblastic leukemia (ALL), in both children and adults. Using molecular techniques of the gen bcr/abl, it is possible to detect the abnormality, in up to the 40% of adult patients. The unsatisfactory results with conventional chemotherapy schemes have determined the intensification of the treatments and the consideration of allogenic bone marrow transplants as the best therapeutic instance. The development of tyrosine kinase inhibitors have become a therapeutic improvement in the treatment of Philadelphia chromosome-positive ALL, being combined with chemotherapy schemes, only in a selected group of patients, even in therapeutic programs that include transplant.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomo Filadélfia
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudo:
Evaluation_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Child
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article