Vitamin A supplementation for different periods alters oxidative parameters in lungs of rats.
J Med Food
; 12(6): 1375-80, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-20041796
ABSTRACT
Lungs require an adequate supply of vitamin A (retinol) for normal embryonic development, postnatal maturation, and maintenance and repair during adult life. However, recent intervention studies revealed that supplementation with retinoids resulted in higher incidence of lung cancer, although the mechanisms underlying this effect are still unknown. Here, we studied the effect of vitamin A supplementation on oxidative stress parameters in lungs of Wistar rats. Vitamin A supplementation at either therapeutic (1,000 and 2,500 IU/kg) or excessive (4,500 and 9,000 IU/kg) doses for 3, 7, or 28 days induced lipid peroxidation, protein carbonylation, and oxidation of protein thiol groups, as well as change in catalase and superoxide dismutase activity. Together, these results suggest that vitamin A supplementation causes significant changes in redox balance, which are frequently associated with severe lung dysfunction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina A
/
Estresse Oxidativo
/
Suplementos Nutricionais
/
Pulmão
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article