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[Calcium antagonists: current and future applications based on new evidence. The mechanisms on lowering serum uric acid level by calcium channel blockers].
Mizuta, Einosuke; Hamada, Toshihiro; Igawa, Osamu; Shigemasa, Chiaki; Hisatome, Ichiro.
Afiliação
  • Mizuta E; Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University Faculty of Medicine, Japan.
Clin Calcium ; 20(1): 45-50, 2010 Jan.
Article em Ja | MEDLINE | ID: mdl-20048433
In hypertensive subjects, their serum uric acid levels tend to be higher because of decreasing urinary secretion or overproduction of uric acid. Among calcium channel blockers (CCBs) , long acting nifedipine and cilnidipine reveal serum uric acid lowering action. They decrease the production of uric acid precursor in skeletal muscles under anaerobic condition induced by hypertension or insulin resistance. Hyperuricemia is considered to be a risk factor of not only gout but also renal and cardiovascular diseases, thus, it is important to use CCBs without adverse effect on uric acid metabolisms.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Úrico / Bloqueadores dos Canais de Cálcio / Hiperuricemia Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: Ja Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Úrico / Bloqueadores dos Canais de Cálcio / Hiperuricemia Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: Ja Ano de publicação: 2010 Tipo de documento: Article