Analogues of distamycin--synthesis and biological evaluation of new aromatic oligopeptides, potential anticancer agents.

Drozdowska, Danuta; Rusak, Malgorzata; Bielawski, Tomasz; Midura-Nowaczek, Krystyna

Drozdowska, Danuta; Rusak, Malgorzata; Bielawski, Tomasz; Midura-Nowaczek, Krystyna.

Afiliação

Drozdowska D; Department of Organic Chemistry, Medical University, 2A Mickiewicza, 15-222 Bialystok, Poland. Danuta.Drozdowska@umwb.edu.pl

Acta Pol Pharm ; 66(6): 633-8, 2009.

Article em En | MEDLINE | ID: mdl-20050527

ABSTRACT

ABSTRACT

Six new aromatic oligopeptides were synthesized and evaluated for their activity in the standard cell line of the mammalian tumor MCF-7 as well as in a cell-free system employing the topoisomerase I/II inhibition assay.

Assuntos

Antineoplásicos/síntese química; Distamicinas/síntese química; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Distamicinas/farmacologia; Humanos; Inibidores da Topoisomerase

Buscar no Google

Imprimir

XML

PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Distamicinas / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Buscar no Google

Imprimir

XML

PubMed Links