[Significance of the TPS cytokeratin marker in the postoperative follow up of colorectal carcinoma patients]. / Význam cytokeratinového markeru TPS v pooperacním sledováiní nemocných s kolorektálním karcinomem.
Rozhl Chir
; 88(8): 428-33, 2009 Aug.
Article
em Cs
| MEDLINE
| ID: mdl-20055296
ABSTRACT
AIM:
Examination of tumour markers conducive to follow up of the patients with colorectal carcinoma. MATERIAL ANDMETHODS:
The tumour markers were examined in the population of patients with primarily established and histologically verified colorectal adenocarcinoma.RESULTS:
The resection therapy resulted in the decrease in post-operative CEA levels. There were no changes in pre- and post-operative CA 19-9 levels; unlike with post-operative TPS levels having been significantly increased, probably due to reparation processes resulting from the surgery. It can be concluded that pre- and post-operative CEA levels are the most suitable markers to check the effect of surgery. With a 95%-specificity for the establishment of recidives, the highest sensitivity was reached with TPS (83%); the sensitivities of the classical tumour markers CEA and CA 19-9 were significantly lower (41% and 25%, respectively). The results should be interpreted with caution due to a small number of relapses regarding a short follow up and rather local-regional character of the recidives.CONCLUSION:
However, TPS seems to be a promising marker for the follow up of the patients with colorectal carcinoma. Thus, an ideal combination seems to be that of CEA and TPS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Adenocarcinoma
/
Biomarcadores Tumorais
/
Queratina-18
Limite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
Cs
Ano de publicação:
2009
Tipo de documento:
Article