Riboswitch RNAs: regulation of gene expression by direct monitoring of a physiological signal.
RNA Biol
; 7(1): 104-10, 2010.
Article
em En
| MEDLINE
| ID: mdl-20061810
ABSTRACT
Riboswitches are cis-encoded, cis-acting RNA elements that directly sense a physiological signal. Signal response results in a change in RNA structure that impacts gene expression. Elements of this type play an important role in bacteria, where they regulate a variety of fundamental cellular pathways. Riboswitch-mediated gene regulation most commonly occurs by effects on transcription attenuation, to control whether a full-length transcript is synthesized, or on translation initiation, in which case the transcript is constitutively synthesized but binding of the translation initiation complex is modulated. An overview of the role of riboswitch RNAs in bacterial gene expression will be provided, and a few examples are described in more detail to illustrate the types of mechanisms that have been uncovered.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
RNA Bacteriano
/
Transdução de Sinais
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Regulação Bacteriana da Expressão Gênica
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Sequências Reguladoras de Ácido Ribonucleico
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article