Eukaryotic stress granules: the ins and outs of translation.
Mol Cell
; 36(6): 932-41, 2009 Dec 25.
Article
em En
| MEDLINE
| ID: mdl-20064460
ABSTRACT
The stress response in eukaryotic cells often inhibits translation initiation and leads to the formation of cytoplasmic RNA-protein complexes referred to as stress granules. Stress granules contain nontranslating mRNAs, translation initiation components, and many additional proteins affecting mRNA function. Stress granules have been proposed to affect mRNA translation and stability and have been linked to apoptosis and nuclear processes. Stress granules also interact with P-bodies, another cytoplasmic RNP granule containing nontranslating mRNA, translation repressors, and some mRNA degradation machinery. Together, stress granules and P-bodies reveal a dynamic cycle of distinct biochemical and compartmentalized mRNPs in the cytosol, with implications for the control of mRNA function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Fisiológico
/
Biossíntese de Proteínas
/
Grânulos Citoplasmáticos
/
Células Eucarióticas
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article