Sporadic hemiplegic migraine and epilepsy associated with CACNA1A gene mutation.
Epilepsy Behav
; 17(2): 293-5, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-20071244
ABSTRACT
Familial hemiplegic migraine (FHM) is a clinically and genetically heterogeneous disease most commonly linked to CACNA1A gene mutation. Epilepsy rarely occurs in FHM and is seen predominantly with specific CACNA1A gene mutations. Here we report a sporadic case of FHM1 linked to S218L CACNA1A gene mutation with the triad of prolonged hemiplegic migraine, cerebellar symptoms, and epileptic seizures. Epilepsy in this syndrome follows the pattern of isolated unprovoked seizures occurring only during childhood and hemiplegic migraine-provoked seizures occurring during adulthood. Clinical and electrographic status epilepticus can occur during prolonged migraine attacks. We suggest that patients with seizures, ataxia, and hemiplegic migraine be genetically tested for FHM. Patients with prolonged hemiplegic migraine attacks and confusion should be tested with continuous EEG recording to ascertain whether electrographic status is occurring, as intensive antiepileptic treatment not only resolves status but immediately stops hemiplegic migraine and improves associated neurological deficits.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canais de Cálcio
/
Mutação Puntual
/
Enxaqueca com Aura
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Epilepsia
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article