Control of PCNA deubiquitylation in yeast.
Biochem Soc Trans
; 38(Pt 1): 104-9, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-20074044
ABSTRACT
Eukaryotes ubiquitylate the replication factor PCNA (proliferating-cell nuclear antigen) so that it tolerates DNA damage. Although, in the last few years, the understanding of the evolutionarily conserved mechanism of ubiquitylation of PCNA, and its crucial role in DNA damage tolerance, has progressed impressively, little is known about the deubiquitylation of this sliding clamp in most organisms. In the present review, we will discuss potential molecular mechanisms regulating PCNA deubiquitylation in yeast.
Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Antígeno Nuclear de Célula em Proliferação
/
Proteínas de Saccharomyces cerevisiae
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article