Apigenin inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma.
Immunopharmacol Immunotoxicol
; 32(3): 364-70, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20095800
ABSTRACT
Many flavonoids were demonstrated to possess the antiallergic effect. Here we detected whether apigenin, a flavonoid, can attenuate allergen-induced airway inflammation and what is the possible mechanism in a murine model of asthma. Apigenin decreased the degree of the inflammatory cell infiltration, airway hyperresponsiveness, and total immunoglobulin E levels compared with the ovalbumin group. In addition, apigenin triggered the switching of the immune response to allergens toward a T-helper type 1 (Th1) profile. Our data clearly demonstrated that apigenin exhibits an anti-inflammatory activity in a murine asthma model, and can switch the immune response to allergens toward the Th1 profile.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Alérgenos
/
Antiasmáticos
/
Apigenina
/
Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article